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Prednisolone gave a small reduction in mortality at 28 days but this did not reach significance, and there were no improvements in outcomes at 90 days or 1 year.

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Liver function methylprednisolone may not clear from the body at the expected rate in cases where the liver is not working properly.

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Methylprednisolone also interacts with an additional drug called cyclosporine, which is used to suppress your immune system.

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